Publications

All papers

• Lee HT, Fu SY, Weng WH, Chao WC, Hsu YP, Yang NP, Chen YH, Chen SK, Chang CW*. Hanging drop culture reprograms mesenchymal stem cell transcriptome to enhance cell delivery efficiency via attenuated pulmonary entrapment. Drug Delivery and Translational Research 2025, 15(11), 4187-4201. DOI
• Huang WY, Liang NW, Yu LJ, Kuan CH, Chang CW, Wu TC, Liao YT, Wang TW. Hybrid apoptotic body decorated supramolecular hydrogel system for melanoma cancer immunoediting. Chemical Engineering Journal 2025, 526, 171086. DOI
• Cheng MH, Chang CW, Wang J, Bupphathong S, Huang W, Lin CH. 3D-Bioprinted GelMA Scaffold with ASCs and HUVECs for Engineering Vascularized Adipose Tissue. ACS Applied Bio Materials 2024, 7(1), 406-415. DOI
• Weng WH, Wang CY, Yan ZY, Lee HT, Kao CY, Chang CW*. Isolation and characterizations of multidrug-resistant human cancer cells by a biodegradable nano-sensor. Biosensors and Bioelectronics 2024, 249, 115985. DOI
• Yalamandala BN, Huynh TMH, Chiang MR, Weng WH, Chang CW, Chiang WH, Hu SH. Programmed Catalytic Therapy and Antigen Capture-Mediated Dendritic Cells Harnessing Cancer Immunotherapies by In Situ-Forming Adhesive Nanoreservoirs. Advanced Functional Materials 2022, 33(15), 2210644. DOI
• Ravula V, Lo YL, Wu YT, Chang CW, Patri SV, Wang LF. Arginine-tocopherol bioconjugated lipid vesicles for selective pTRAIL delivery and subsequent apoptosis induction in glioblastoma cells. Materials Science and Engineering C 2021, 126, 112189. DOI
• Huang RY, Liu ZH, Weng WH, Chang CW*. Magnetic nanocomplexes for gene delivery applications. Journal of Materials Chemistry B 2021, 9(21), 4267-4286. DOI
• Wu CY, Huang RY, Liao EC, Lin YC, Ho YJ, Chang CW, Chan HL, Huang YZ, Hsieh TH, Fan CH, Yeh CK. A preliminary study of Parkinson's gene therapy via sono-magnetic sensing gene vector for conquering extra/intracellular barriers in mice. Brain Stimulation 2020, 13(3), 786-799. DOI
• Chuang CC, Chen YN, Wang YY, Huang YC, Lin SY, Huang RY, Jang YY, Yang CC, Huang YF, Chang CW*. Stem Cell-Based Delivery of Gold/Chlorin e6 Nanocomplexes for Combined Photothermal and Photodynamic Therapy. ACS Applied Materials and Interfaces 2020, 12(27), 30021-30030. DOI
• Ho YJ, Hsu HC, Kang ST, Fan CH, Chang CW, Yeh CK. Ultrasonic Transdermal Delivery System with Acid-Base Neutralization-Generated CO₂ Microbubble Cavitation. ACS Applied Bio Materials 2020, 3(4), 1968-1975. DOI
• Hsu RS, Chen PY, Fang JH, Chen YY, Chang CW, Lu YJ, Hu SH. Adaptable Microporous Hydrogels of Propagating NGF-Gradient by Injectable Building Blocks for Accelerated Axonal Outgrowth. Advanced Science 2019, 6(16), 1900520. DOI
• Chuang CC, Cheng CC, Chen PY, Lo C, Chen YN, Shih MH, Chang CW*. Gold nanorod-encapsulated biodegradable polymeric matrix for combined photothermal and chemo-cancer therapy. International Journal of Nanomedicine 2019, 14, 181-193. DOI
• Huang RY, Lin YH, Lin SY, Li YN, Chiang CS, Chang CW*. Magnetic ternary nanohybrids for nonviral gene delivery of stem cells and applications on cancer therapy. Theranostics 2019, 9(8), 2411-2423. DOI
• Huang FYJ, Hung CC, Chang CW, Chao JH, Hsieh BT. Evaluation of injectable chitosan-based co-crosslinking hydrogel for local delivery of 188Re-LIPO-DOX to breast-tumor-bearing mouse model. Anticancer Research 2018, 38(8), 4651-4659. DOI
• Li TN, Wu YJ, Tsai HW, Sun CP, Wu YH, Wu HL, Pei YN, Lu KY, Yen TTC, Chang CW, Chan HL, Tao MH, Liou JY, Chang MDT, Su IJ, Wang LHC. Intrahepatic hepatitis B virus large surface antigen induces hepatocyte hyperploidy via failure of cytokinesis. Journal of Pathology 2018, 245(4), 502-513. DOI
• Lin SY, Huang RY, Liao WC, Chuang CC, Chang CW*. Multifunctional PEGylated albumin/IR780/iron oxide nanocomplexes for cancer photothermal therapy and MR imaging. Nanotheranostics 2018, 2(2), 106-116. DOI
• Wang L, Chen Y, Lin HY, Hou YT, Yang LC, Sun AY, Liu JY, Chang CW, Wan D. Near-IR-absorbing gold nanoframes with enhanced physiological stability and improved biocompatibility for in vivo biomedical applications. ACS Applied Materials and Interfaces 2017, 9(4), 3873-3884. DOI
• Huang WC, Lu IL, Chiang WH, Lin YW, Tsai YC, Chen HH, Chang CW, Chiang CS, Chiu HC. Tumortropic adipose-derived stem cells carrying smart nanotherapeutics for targeted delivery and dual-modality therapy of orthotopic glioblastoma. Journal of Controlled Release 2017, 254, 119-130. DOI
• Yen TTC, Yang A, Chiu WT, Li TN, Wang LH, Wu YH, Wang HC, Chen L, Wang WC, Huang W, Chang CW, Chang MDT, Shen MR, Su IJ, Wang LHC. Hepatitis B virus preS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability. Oncotarget 2016, 7(17), 23346-23360. DOI
• Lin CJ, Kuan CH, Wang LW, Wu HC, Chen Y, Chang CW, Huang RY, Wang TW. Integrated self-assembling drug delivery system possessing dual responsive and active targeting for orthotopic ovarian cancer theranostics. Biomaterials 2016, 90, 12-26. DOI
• Wu YF, Wu HC, Kuan CH, Lin CJ, Wang LW, Chang CW, Wang TW. Multi-functionalized carbon dots as theranostic nanoagent for gene delivery in lung cancer therapy. Scientific Reports 2016, 6(1), 21170. DOI
• Chen WJ, Huang FYJ, Chang HY, Lee TW, Chang CW*, Lo JM*. The novel preparation of ^99mTc(I)-labeled human serum albumin (HSA) nanoparticles as a SPECT imaging agent. Journal of Radioanalytical and Nuclear Chemistry 2016, 307(1), 141-150. DOI
• Wang SH, Chang CW, Chou HC. 5-Methoxytryptophan-dependent inhibition of oral squamous cell carcinoma metastasis. Electrophoresis 2015, 36(17), 2027-2034. DOI
• Hsieh CC, Kang ST, Lin YH, Ho YJ, Wang CH, Yeh CK, Chang CW*. Biomimetic acoustically-responsive vesicles for theranostic applications. Theranostics 2015, 5(11), 1264-1274. DOI
• Lai PY, Huang RY, Lin SY, Lin YH, Chang CW*. Biomimetic stem cell membrane-camouflaged iron oxide nanoparticles for theranostic applications. RSC Advances 2015, 5(119), 98222-98230. DOI
• Chuang CC, Chang CW*. Complexation of bioreducible cationic polymers with gold nanoparticles for improving stability in serum and application on nonviral gene delivery. ACS Applied Materials and Interfaces 2015, 7(14), 7724-7731. DOI
• Huang FY, Lee TW, Chang CH, Chen LC, Hsu WH, Chang CW*, Lo JM*. Evaluation of ¹⁸⁸Re-labeled PEGylated nanoliposome as a radionuclide therapeutic agent in an orthotopic glioma-bearing rat model. International Journal of Nanomedicine 2015, 10, 463-473. DOI
• Huang WC, Shen MY, Chen HH, Lin SC, Chiang WH, Wu PH, Chang CW, Chiang CS, Chiu HC. Monocytic delivery of therapeutic oxygen bubbles for dual-modality treatment of tumor hypoxia. Journal of Controlled Release 2015, 220, 738-750. DOI
• Lee KCJ, Chen YH, Lin HY, Cheng CC, Chen PY, Wu TY, Shih MH, Wei KH, Li LJ, Chang CW. Plasmonic gold nanorods coverage influence on enhancement of the photoluminescence of two-dimensional MoS2 monolayer. Scientific Reports 2015, 5(1), 16374. DOI
• Huang RY, Chiang PH, Hsiao WC, Chuang CC, Chang CW*. Redox-Sensitive Polymer/SPIO Nanocomplexes for Efficient Magnetofection and MR Imaging of Human Cancer Cells. Langmuir 2015, 31(23), 6523-6531. DOI
• Chang CW, Hwang Y, Brafman D, Hagan T, Phung C, Varghese S. Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells. Biomaterials 2013, 34(4), 912-921. DOI
• Chiang WH, Huang WC, Chang CW, Shen MY, Shih ZF, Huang YF, Lin SC, Chiu HC. Functionalized polymersomes with outlayered polyelectrolyte gels for potential tumor-targeted delivery of multimodal therapies and MR imaging. Journal of Controlled Release 2013, 168(3), 280-288. DOI
• Kolodziej CM, Chang CW, Maynard HD. Glutathione S-transferase as a general and reversible tag for surface immobilization of proteins. Journal of Materials Chemistry 2011, 21(5), 1457-1461. DOI
• Zhang C, Sangaj N, Hwang Y, Phadke A, Chang CW, Varghese S. Oligo(trimethylene carbonate)-poly(ethylene glycol)-oligo(trimethylene carbonate) triblock-based hydrogels for cartilage tissue engineering. Acta Biomaterialia 2011, 7(9), 3362-3369. DOI
• Phadke A, Chang CW, Varghese S. Functional Biomaterials for Controlling Stem Cell Differentiation. Studies in Mechanobiology, Tissue Engineering and Biomaterials 2010, 19-44. DOI
• Sangaj N, Kyriakakis P, Yang D, Chang CW, Arya G, Varghese S. Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells. Biomacromolecules 2010, 11(12), 3294-3300. DOI
• Brafman DA, Chang CW, Fernandez A, Willert K, Varghese S, Chien S. Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. Biomaterials 2010, 31(34), 9135-9144. DOI
• Chang CW, van Spreeuwel A, Zhang C, Varghese S. PEG/clay nanocomposite hydrogel: A mechanically robust tissue engineering scaffold. Soft Matter 2010, 6(20), 5157. DOI
• Chang CW, Nguyen TH, Maynard HD. Thermoprecipitation of glutathione S-transferase by glutathione- poly(Nisopropylacrylamide) prepared by RAFT polymerization. Macromolecular Rapid Communications 2010, 31(19), 1691-1695. DOI
• Chang CW, Bays E, Tao L, Alconcel SNS, Maynard HD. Differences in cytotoxicity of poly(PEGA)s synthesized by reversible addition-fragmentation chain transfer polymerization. Chemical Communications 2009(24), 3580. DOI
• Yockman JW, Choi D, Whitten MG, Chang CW, Kastenmeier A, Erickson H, Albanil A, Lee M, Kim SW, Bull DA. Polymeric gene delivery of ischemia-inducible VEGF significantly attenuates infarct size and apoptosis following myocardial infarct. Gene Therapy 2009, 16(1), 127-135. DOI
• Vázquez-Dorbatt V, Tolstyka ZP, Chang CW, Maynard HD. Synthesis of a pyridyl disulfide end-functionalized glycopolymer for conjugation to biomolecules and patterning on gold surfaces. Biomacromolecules 2009, 10(8), 2207-2212. DOI
• Bays E, Tao L, Chang CW, Maynard HD. Synthesis of semitelechelic maleimide poly(PEGA) for protein conjugation by RAFT polymerization. Biomacromolecules 2009, 10(7), 1777-1781. DOI
• Chang CW, Christensen LV, Lee M, Kim SW. Efficient expression of vascular endothelial growth factor using minicircle DNA for angiogenic gene therapy. Journal of Controlled Release 2008, 125(2), 155-163. DOI
• Ou M, Wang XL, Xu R, Chang CW, Bull DA, Kim SW. Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity. Bioconjugate Chemistry 2008, 19(3), 626-633. DOI
• Heredia KL, Nguyen TH, Chang CW, Bulmus V, Davis TP, Maynard HD. Reversible siRNA-polymer conjugates by RAFT polymerization. Chemical Communications 2008(28), 3245. DOI
• Kim WJ, Chang CW, Lee M, Kim SW. Efficient siRNA delivery using water soluble lipopolymer for anti-angiogenic gene therapy. Journal of Controlled Release 2007, 118(3), 357-363. DOI
• Chang CW, Choi D, Kim WJ, Yockman JW, Christensen LV, Kim YH, Kim SW. Non-ionic amphiphilic biodegradable PEG-PLGA-PEG copolymer enhances gene delivery efficiency in rat skeletal muscle. Journal of Controlled Release 2007, 118(2), 245-253. DOI
• Yockman JW, Kim WJ, Chang CW, Kim SW. Non-viral delivery of interleukin-2 and soluble Flk-1 inhibits metastatic and primary tumor growth in renal cell carcinoma. Gene Therapy 2007, 14(19), 1399-1405. DOI
• Christensen LV, Chang CW, Yockman JW, Conners R, Jackson H, Zhong Z, Feijen J, Bull DA, Kim SW. Reducible poly(amido ethylenediamine) for hypoxia-inducible VEGF delivery. Journal of Controlled Release 2007, 118(2), 254-261. DOI
• Christensen LV, Chang CW, Kim WJ, Kim SW, Zhong Z, Lin C, Engbersen JFJ, Feijen J. Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery. Bioconjugate Chemistry 2006, 17(5), 1233-1240. DOI
• Bikram M, Lee M, Chang CW, Janát-Amsbury MM, Kern SE, Kim SW. Long-circulating DNA-complexed biodegradable multiblock copolymers for gene delivery: Degradation profiles and evidence of dysopsonization. Journal of Controlled Release 2005, 103(1), 221-233. DOI

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